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Introduction to Povidone (PVP K90):
Povidone, also known as polyvinylpyrrolidone or PVP, is a water-soluble polymer widely used in the pharmaceutical industry for its unique properties. PVP K90 is a specific grade of Povidone characterized by its high molecular weight. This excipient is derived from the monomer N-vinyl-2-pyrrolidone and is valued for its versatility, biocompatibility, and ability to enhance various aspects of pharmaceutical formulations.
Function of Povidone (PVP K90) in Pharmaceutical Excipients:
PVP K90 serves multiple functions in pharmaceutical formulations, with its primary role as a binder, film-former, and solubilizer. As a binder, it enhances the cohesiveness of powdered drug mixtures during tablet compression, ensuring the formation of tablets with optimal mechanical strength. PVP K90's film-forming properties make it suitable for coating tablets, providing a protective layer that improves stability and facilitates controlled drug release. Additionally, PVP K90 acts as a solubilizer, enhancing the solubility of poorly water-soluble drugs and improving their bioavailability.
Application of Povidone (PVP K90) in Pharmaceutical Formulations:
PVP K90 finds extensive application in the pharmaceutical industry, particularly in the production of tablets, capsules, and film-coated dosage forms. In tablet manufacturing, it is utilized as a binder to improve tablet integrity and as a film-former for coating applications, offering a protective layer that masks taste and odor. PVP K90's solubilizing properties make it a valuable component in oral solid dosage forms, enhancing the dissolution rates of poorly water-soluble drugs. Its compatibility with a wide range of drug formulations and its ability to contribute to drug stability and bioavailability make PVP K90 a versatile and widely employed excipient in the pharmaceutical field.
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