Pharmaceutical Raw Mateial Rupatadine Fumarate Powder CAS 182349-12-8

• Customization: Available
• Powder: Yes
• Certification: GMP
• Model NO.: Rupatadine Fumarate
• Suitable for: Adult
• State: Solid
• Quality: High
• Colour: White Powder
• MOQ: 1 Kilograms
• Storage: Cool Dry Place
• Package: 1kg/Bag, 25kg/Drum
• Delivery Time: 15-25 Days
• Use: Medicine
• Place of Origin: Anhui, China
• Advantage: Fctory & Professional
• Brand Name: Keynovo
• Shelf Life: 2 Years
• Sample: Avaliable
• Transport Package: Safe Packing
• Trademark: keynovo
• Origin: China
• Production Capacity: 50000 Kg Per Week

Product Description

Product Description

Product Description:
Rupatadine Fumarate is a second-generation antihistamine and platelet-activating factor (PAF) antagonist, formulated as a white to off-white crystalline powder. This lipophilic compound exhibits excellent solubility in organic solvents and limited solubility in water, ensuring stability in solid dosage forms (e.g., tablets, oral solutions). Produced under cGMP conditions, it is free from genotoxic impurities and residual solvents. Rupatadine Fumarate demonstrates pH-dependent solubility, optimal absorption in the small intestine, and a plasma half-life of 5-6 hours. It is packaged in moisture-resistant, light-protective containers at controlled room temperature (20-25°C).

Function:

1. Dual Antihistamine & Anti-PAF Activity:
   • H1 Receptor Antagonism: Blocks histamine H1 receptors, inhibiting allergic responses (e.g., pruritus, vasodilation).
   • PAF Receptor Inhibition: Reduces inflammation by antagonizing platelet-activating factor (PAF), a key mediator in allergic and anaphylactic reactions.
2. Anti-Inflammatory Effects: Suppresses cytokine release (e.g., IL-4, IL-6) and eosinophil infiltration in allergic pathways.
3. Non-Sedating Profile: Minimal penetration of the blood-brain barrier, avoiding CNS drowsiness common to first-generation antihistamines.
4. Rapid Onset & Prolonged Action: Achieves peak plasma concentration within 1-2 hours and sustains 24-hour efficacy with once-daily dosing.
5. Metabolic Stability: Primarily metabolized by CYP3A4 to active metabolites, enhancing therapeutic duration.
6. Low Cardiac Risk: No significant QT interval prolongation at therapeutic doses.

Applications:

1. Allergic Rhinitis Management:
   • Seasonal & Perennial Allergic Rhinitis: Relieves sneezing, rhinorrhea, nasal congestion, and ocular itching (10 mg/day oral tablets).
2. Chronic Urticaria Treatment:
   • Reduces wheals, erythema, and pruritus in idiopathic or autoimmune urticaria.
3. PAF-Mediated Conditions:
   • Adjunct therapy for asthma exacerbations, atopic dermatitis, or insect bite reactions involving PAF-driven inflammation.
4. Pediatric Use:
   • Approved for children ≥12 years (weight-adjusted dosing) in select regions.
5. Combination Therapy:
   • Synergizes with intranasal corticosteroids for refractory nasal symptoms.
6. Veterinary Applications:
   • Off-label use in allergic dermatitis management for dogs and cats (veterinary-compounded formulations).
7. Research Applications:
   • In vitro studies exploring PAF receptor signaling pathways and histamine-PAF crosstalk in allergy models.
   • Drug interaction studies with CYP3A4 inhibitors/inducers (e.g., ketoconazole, rifampicin).

Rupatadine Fumarate stands out as a dual-action therapeutic agent, uniquely addressing both histamine and PAF-mediated allergic mechanisms. Its favorable safety profile, 24-hour efficacy, and compatibility with polypharmacy make it a frontline choice for allergists and dermatologists. By targeting multiple inflammatory pathways, it offers enhanced symptom control for patients with complex or refractory allergic disorders, bridging gaps in conventional antihistamine therapy.

 

 

Company Profile

FAQ

1. Are you a manufacturer or trading company?

A: We are a manufacturer and welcome to visit our factory.
 
2. How to confirm the product quality before placing an order?
A: We can provide you with the sample. Also, we have the inspection report issued by the authoritative third-party testing agency.
 
3: What's your MOQ?
A:  It depends on different products. We accept sample orders. Also for some products, we can provide you with a free sample.
 
4:Do you provide after-sales service?
A: We provide 24-hour customer service. If you encounter any product quality problems or transportation problems, please feel free to contact us.
 
5:How about delivery time and method?
A: We usually ship within 3-5 working days after payments. 
We can make ships by sea, air, and express. Also can make door-to-door shipping. 
 
6:How to solve the after-sale disputes?
A: We accept changing or refunding services if there is any quality problem.