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Introduction to Povidone (PVP K90):
Povidone, specifically PVP K90, is a water-soluble polymer derived from N-vinyl-2-pyrrolidone monomers. With a high molecular weight, PVP K90 is a significant pharmaceutical excipient known for its versatile applications. This polymer plays a crucial role in the pharmaceutical industry, contributing to the development of various drug formulations and improving their performance.
Function of Povidone (PVP K90) in Pharmaceutical Excipients:
PVP K90 serves multiple functions in pharmaceutical formulations, primarily functioning as a binder, film-former, and solubilizer. As a binder, PVP K90 enhances the cohesion of powdered drug mixtures during tablet compression, ensuring the formation of tablets with optimal mechanical strength. Its film-forming properties make it suitable for coating tablets, providing a protective layer that enhances stability and facilitates controlled drug release. Additionally, PVP K90 acts as a solubilizer, improving the solubility of poorly water-soluble drugs, ultimately enhancing their bioavailability.
Application of Povidone (PVP K90) in Pharmaceutical Formulations:
PVP K90 finds extensive application in the pharmaceutical industry, particularly in the production of tablets, capsules, and film-coated dosage forms. In tablet manufacturing, it is used as a binder to improve tablet integrity and as a film-former for coating applications, offering a protective layer that masks taste and odor. PVP K90's solubilizing properties make it a valuable component in oral solid dosage forms, enhancing the dissolution rates of poorly water-soluble drugs. Its compatibility with a wide range of drug formulations and its ability to contribute to drug stability and bioavailability make PVP K90 a versatile and widely employed excipient in the pharmaceutical field.
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