| Customization: | Available |
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| CAS No.: | Customization, 9004-32-4 |
| Formula: | Customization |
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Introduction to Carboxymethylcellulose Sodium (CMC-Na):
Carboxymethylcellulose Sodium (CMC-Na) is a water-soluble cellulose derivative widely employed in the pharmaceutical industry as a versatile excipient. Derived from cellulose through a carboxymethylation process, CMC-Na exhibits unique rheological and mucoadhesive properties, making it a valuable component in various pharmaceutical formulations. Its biocompatibility and ability to form transparent, viscous solutions contribute to its widespread use in drug delivery systems.
Function of CMC-Na in Pharmaceutical Excipients:
CMC-Na serves multiple essential functions as a pharmaceutical excipient, with its primary role as a binder in solid dosage forms. By enhancing the cohesion of powdered drug mixtures, CMC-Na facilitates the tabletting process, resulting in tablets with improved hardness and disintegration characteristics. Furthermore, CMC-Na acts as a thickening and stabilizing agent in liquid formulations, contributing to the viscosity and uniformity of suspensions and syrups. Its mucoadhesive properties make it particularly useful in oral formulations, promoting prolonged contact with mucosal surfaces and improving drug absorption.
Application of CMC-Na in Pharmaceutical Formulations:
The applications of CMC-Na in pharmaceutical formulations are diverse and impactful. In tablet manufacturing, CMC-Na is employed as a binder to enhance the mechanical strength of tablets, ensuring their structural integrity. Its compatibility with a wide range of active pharmaceutical ingredients makes it suitable for various therapeutic classes. In liquid formulations, such as oral suspensions and syrups, CMC-Na imparts viscosity, preventing sedimentation and providing a uniform distribution of particles. Moreover, its role in ophthalmic formulations as a viscosity-enhancing agent contributes to prolonged drug residence time on the ocular surface. CMC-Na's versatility and compatibility make it a key player in optimizing the performance and patient acceptability of pharmaceutical formulations.
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