| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Medicinal field:
Anti-tumor drug: FDA approved emulsion formulation (Sonus
Pharmaceuticals)
Anti-HIV drugs: Agenerase (Amprenavir) and APTIVUS (Telanavir).
Anti-hepatitis C virus (HCV) drugs: VIEKERA Pack tablets.
Ophthalmic medications: dry eye; prevention of contact lens wear; healing of the
postoperative cornea.
Treatment of vitamin E deficiency caused by chronic bile deficiency
Food and Cosmetics Field :
Converts a wide range of natural nutrients into stable, water-soluble liquids or powders
Has antioxidant and anti-aging effects
Marketing Analysis: TPGS has been applied in large quantities abroad, but the domestic application has just started. The pharmaceutical grade TPGS developed by the company will fill the domestic gap and has a broad market prospect.
TPGS applications in the pharmaceutical field : It is mainly used as excipient and absorption enhancer. Due to its emulsifying and solubilizing effects, it can effectively improve the bioavailability of drugs. Thus, it can reduce the amount of drug use and reduce the toxic side effects of drugs.
Vitamin E polyethylene glycol succinate (TPGS) is a water-soluble derivative of natural vitamin E that has been widely used in pharmaceutical formulations. It is particularly valued for its ability to enhance the bioavailability of poorly soluble drugs, improve drug solubility, and act as a solubilizer, emulsifier, and absorption enhancer. The applications of TPGS in products approved by the USFDA are diverse and span various drug delivery systems. Here are some key applications:
TPGS is often used to improve the solubility of poorly water-soluble drugs. This is crucial for increasing the bioavailability of these drugs. The mechanism involves the reduction of interfacial tension and the formation of micelles that encapsulate the hydrophobic drug molecules, enhancing their dissolution.
In formulations requiring stable emulsions, TPGS serves as an effective emulsifying agent. Its amphiphilic nature allows it to stabilize oil-in-water emulsions, which is particularly useful in topical formulations and certain oral and parenteral formulations.
TPGS has been shown to inhibit P-glycoprotein (P-gp), a drug efflux transporter that reduces the absorption of many drugs. By inhibiting P-gp, TPGS enhances the absorption and bioavailability of these drugs. This is particularly beneficial for drugs that are substrates of P-gp.
In some controlled release formulations, TPGS is used to modulate the release profile of the active pharmaceutical ingredient (API). This can be achieved by incorporating TPGS into matrix systems or coatings that control the drug release rate.
TPGS is an integral component of lipid-based drug delivery systems, such as liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs). These systems can improve the stability, solubility, and bioavailability of encapsulated drugs.
TPGS is commonly used in the formulation of nanoparticles, which can be designed for targeted drug delivery. The incorporation of TPGS in these systems can improve the stability and efficacy of the nanoparticles.
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