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Dehydro ivabradine is a derivative of ivabradine, a medication used primarily for the treatment of angina pectoris and heart failure. It belongs to a class of drugs known as selective If channel inhibitors, which work by reducing the heart rate and myocardial oxygen consumption. Dehydro ivabradine is a modified form of ivabradine that exhibits enhanced potency and improved pharmacokinetic properties.
FunctionThe primary function of dehydro ivabradine is to selectively inhibit the If (funny current) channels in the sinoatrial node of the heart. By blocking these channels, it reduces the spontaneous diastolic depolarization and prolongs the repolarization phase, resulting in a decreased heart rate. This effect is especially beneficial in the treatment of conditions such as angina and heart failure, where lowering the heart rate can improve myocardial oxygen supply-demand balance and enhance cardiac function.
ApplicationDehydro ivabradine has promising applications in the field of cardiology. It can be used as a therapeutic agent for the management of chronic stable angina, particularly in patients who cannot tolerate or have contraindications to beta-blockers. By reducing the heart rate, dehydro ivabradine helps to alleviate the symptoms of angina, such as chest pain and shortness of breath, and improve exercise tolerance.
Furthermore, dehydro ivabradine shows potential in the treatment of heart failure. It has been found to improve cardiac contractility and reduce myocardial remodeling, leading to improved cardiac function and quality of life for heart failure patients. The selective action of dehydro ivabradine on the If channels makes it an attractive alternative to traditional heart failure medications.
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