| Customization: | Available |
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| CAS No.: | 103300-74-9, Customization |
| Formula: | C17h31n7o9, Customization |
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Introduction:
Taltirelin is a synthetic peptide hormone and a derivative of thyrotropin-releasing hormone (TRH). It was developed for its selective action on the hypothalamus-pituitary-thyroid (HPT) axis, specifically targeting the TRH receptor. Taltirelin is known by its international nonproprietary name (INN) and has shown promising therapeutic potential in various medical conditions related to the thyroid gland.
Function:
Taltirelin primarily functions by stimulating the release of thyroid-stimulating hormone (TSH) from the pituitary gland. This, in turn, leads to the production and release of thyroid hormones, including thyroxine (T4) and triiodothyronine (T3), from the thyroid gland. Taltirelin's ability to enhance the HPT axis activity makes it a valuable tool for diagnosing and treating disorders associated with thyroid function, such as hypothyroidism and certain types of thyroid cancer.
Application:
Taltirelin finds its application mainly in the management of hypothyroidism, a condition characterized by an underactive thyroid gland. It can be used as an adjunct therapy alongside levothyroxine, a synthetic form of thyroxine, to optimize the treatment response in patients with central hypothyroidism, which is caused by a dysfunction in the hypothalamus or pituitary gland.
Additionally, Taltirelin has shown potential as a diagnostic tool for evaluating the functionality of the hypothalamic-pituitary-thyroid axis. By administering Taltirelin and measuring the subsequent TSH response, healthcare professionals can assess the integrity of the HPT axis and distinguish between primary hypothyroidism (caused by thyroid gland dysfunction) and central hypothyroidism (caused by hypothalamic or pituitary dysfunction).
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