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Introduction:
Dasatinib is a targeted anticancer that belongs to the class of tyrosine kinase inhibitors. It is used in the treatment of certain types of leukemia, including chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
Function:
dasatinib works by inhibiting the activity of specific tyrosine kinases, such as BCR-ABL, SRC, and c-KIT, which are involved in the growth and proliferation of cancer cells. By blocking the signals that promote the uncontrolled growth of cancer cells, dasatinib helps to slow down or suppress the progression of leukemia.
Application:
Dasatinib has shown significant efficacy in patients with CML, including those who have developed resistance to other tyrosine kinase inhibitors. Similarly, Ph+ ALL is a rare and aggressive form of acute lymphoblastic leukemia that is characterized by the presence of a specific genetic abnormality called the Philadelphia chromosome.
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