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Introduction:
Edotreotide, also known as [D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys]-Thr(ol), is a synthetic peptide analog of somatostatin. It is derived from the natural hormone somatostatin and modified to enhance its stability and pharmacological properties. Edotreotide is typically available as a powder form, which allows for convenient use and formulation in various applications.
Function:
Edotreotide acts as a somatostatin receptor agonist, binding to somatostatin receptors and exerting inhibitory effects on the secretion of certain hormones and peptides. It specifically targets somatostatin receptor subtype 2 (SSTR2), which is highly expressed in neuroendocrine tumors. By activating SSTR2, edotreotide helps to regulate hormone levels and inhibit tumor growth.
Application:
Edotreotide has found significant application in the field of nuclear medicine, particularly in diagnostic imaging and therapeutic interventions. In diagnostic imaging, it is radiolabeled with technetium-99m or gallium-68 to perform somatostatin receptor scintigraphy or positron emission tomography (PET) imaging, respectively. This allows for the visualization and localization of somatostatin receptor-positive tumors, such as neuroendocrine tumors, which helps in diagnosis, staging, and monitoring treatment response.
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