| Customization: | Available |
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| CAS No.: | Customs, Customs |
| Formula: | Customs, Customs |
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Introduction:
Mizoribine is a purine nucleoside analogue that inhibits the proliferation of T and B lymphocytes by interfering with their DNA synthesis. It acts selectively on the immune system and helps to prevent rejection reactions in organ transplantation.
Function:
Mizoribine functions as an immunosuppressant by specifically targeting the enzyme inosine monophosphate dehydrogenase (IMPDH), which is involved in the de novo synthesis of guanosine nucleotides. By inhibiting IMPDH, Mizoribine disrupts the synthesis of DNA and RNA in immune cells, thereby suppressing their proliferation and immune response.
Application:
Mizoribine is primarily used as an immunosuppressive agent in solid organ transplantation, particularly in kidney transplantation. It is often used in combination with other immunosuppressive drugs to prevent graft rejection and improve the success rate of transplantation. Furthermore, Mizoribine has also shown efficacy in the treatment of certain autoimmune diseases, such as lupus nephritis and rheumatoid arthritis, where it helps to suppress the abnormal immune response and reduce disease activity.
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