| Customization: | Available |
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| CAS No.: | 71610-00-9 |
| Environmental Protection: | Yes |
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Product Description:
Cephalomannine, also known as 7-epi-10-deacetylbaccatin III, is a naturally occurring diterpenoid found in the bark and needles of the yew tree (Taxus species). It is structurally similar to the well-known anticancer compound paclitaxel (Taxol), sharing a similar taxane backbone. Cephalomannine appears as a white to off-white crystalline powder. Due to its close structural relationship with paclitaxel, it is studied for its potential in the development of new chemotherapeutic agents and its role as an intermediate in the semisynthetic production of paclitaxel and other taxanes.
Function:
Anticancer Activity: Cephalomannine exhibits anticancer properties similar to paclitaxel. It works by stabilizing microtubules and preventing their depolymerization, which disrupts cell division and leads to cell death, particularly in rapidly dividing cancer cells.
Intermediate in Taxane Synthesis: Cephalomannine serves as an important intermediate in the semisynthesis of paclitaxel and other taxane-based chemotherapeutic agents. Its chemical structure allows for modifications that enhance efficacy and reduce side effects.
Potential Pharmacological Research: Cephalomannine is used in pharmacological research to explore new derivatives and analogs with improved therapeutic profiles for cancer treatment.
Application:
Pharmaceutical Industry: Cephalomannine is utilized in the pharmaceutical industry as a precursor in the synthesis of paclitaxel and other taxane-based drugs. These drugs are essential in the treatment of various cancers, including breast, ovarian, lung, and pancreatic cancers.
Cancer Research: In cancer research, cephalomannine is studied for its direct anticancer effects and its potential to serve as a lead compound for developing new chemotherapeutic agents. Researchers investigate its mechanism of action, efficacy, and safety profiles in preclinical and clinical studies.
Biotechnological Applications: Cephalomannine is used in biotechnological processes to produce taxanes through cell culture and genetic engineering techniques. This approach aims to enhance the yield and sustainability of taxane production.
Drug Development: The compound is a valuable tool in drug development programs focusing on modifying the taxane structure to create novel drugs with improved pharmacokinetics, reduced toxicity, and enhanced anticancer activity.
Medical Research: Cephalomannine is employed in medical research to understand its interactions with microtubules and its role in cell cycle regulation. Studies aim to uncover new therapeutic targets and strategies for combating drug-resistant cancer cells.
Quality Control in Manufacturing: In the production of taxane-based drugs, cephalomannine is used in quality control processes to ensure the purity, potency, and consistency of the final pharmaceutical products.
Potential Therapeutic Agents: Research into cephalomannine extends beyond cancer treatment, exploring its potential as a therapeutic agent for other diseases where microtubule stabilization might be beneficial, such as neurodegenerative disorders.
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