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Acotiamide Hydrochloride Trihydrate functions as a selective acetylcholinesterase inhibitor, which means it inhibits the enzyme responsible for breaking down acetylcholine. By inhibiting acetylcholinesterase, Acotiamide Hydrochloride Trihydrate helps to increase the levels of acetylcholine in the gastrointestinal tract. This, in turn, enhances the coordination and motility of the digestive muscles, leading to improved gastric emptying, reduced feelings of fullness, and relief from symptoms associated with functional dyspepsia.
Furthermore, Acotiamide Hydrochloride Trihydrate has been found to have minimal systemic absorption, meaning it primarily acts locally within the gastrointestinal tract. This characteristic contributes to its relative safety profile and lower risk of systemic side effects.
ApplicationAcotiamide Hydrochloride Trihydrate has primarily been studied for its application in the treatment of functional dyspepsia. Functional dyspepsia is a common disorder characterized by persistent or recurrent upper abdominal discomfort or pain, bloating, and early satiety without any underlying identifiable cause. Studies have shown that Acotiamide Hydrochloride Trihydrate can alleviate the symptoms of functional dyspepsia by improving gastric emptying and reducing abnormal gastric motility.
Additionally, Acotiamide Hydrochloride Trihydrate has also been studied for its potential application in other gastrointestinal disorders such as gastroesophageal reflux disease (GERD) and non-ulcer dyspepsia. It exerts its therapeutic effects by increasing the release of acetylcholine, a neurotransmitter that plays a key role in gastrointestinal motility regulation.