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Introduction:
Linaclotide is a peptide-based medication that is used primarily for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It belongs to a class of drugs called guanylate cyclase-C agonists. Linaclotide works by stimulating the guanylate cyclase-C receptors in the intestine, which leads to increased fluid secretion and accelerated gastrointestinal transit, thus relieving symptoms of constipation.
Function:
The main function of linaclotide is to alleviate symptoms associated with irritable bowel syndrome with constipation and chronic idiopathic constipation. By targeting the guanylate cyclase-C receptors in the intestine, linaclotide increases the production of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels promote fluid secretion into the intestines and enhance bowel movements, which helps to relieve constipation and reduce abdominal pain in patients suffering from these conditions.
Application:
Linaclotide is mainly prescribed for patients diagnosed with irritable bowel syndrome with constipation and chronic idiopathic constipation. It is available in oral capsule form and should be taken once daily on an empty stomach, preferably at least 30 minutes before breakfast. The dosage may vary depending on the condition being treated and the patient's response to the medication. It is important to follow the instructions provided by the healthcare professional and not exceed the recommended dosage.
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